Biocatalytic process intensification

Biocatalytic Process Intensification Using Microreaction Technology... 

A general review of continuous processing/process intensification in the pharmaceutical industry has been made by Rubin ef a. [22], while the use of PI novel technologies to reshape the petrochemical and biotechnology industries has been analyzed by Hahn [23] and Akay [24], respectively. Recent advances in biotechnology process intensification have also been reviewed by Choe ef al. [25] and Akay et al. [26]. The use of monoliths as biocatalytic reactors to achieve PI by smart gas-liquid contact has been reviewed by Kreutzer ef al. [27]. 

It will be essential to integrate correctly the development of new biocatalytic routes into chemical process development using retrosynthetic approaches [10, 26], but it will also be important to consider process issues from the start. These include balancing of reaction schemes, selection of reactors, and process intensification and integration. 

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