Biocatalytic Asymmetric Oxidations with Other Enzymes

Biocatalytic Asymmetric Oxidations with Other Enzymes 

Many unusual biocatalytic asymmetric oxidation reactions like oxidative cychza-tion, oxidative ring expansion, oxidative deamination, or oxidative decarboxylation were discovered in the course of studies in natural product biosynthesis and the involved enzyme functions continue to be of great interest. 

Oxidative ring expansion by an additional carbon atom is performed by expan-dases different from the Baeyer-VilUger monooxygenases capable of introdudng oxygen into cycUc ketones. The Fe(II)- and 2-oxoglutarate-dependent oxygenase 

Useful whole cell asymmetric oxidations of methyl groups to carboxyl groups have been found by classical microbiological screening as for the microbial oxidation of prochiral 2-methyl-l,3-propandiol to (R)-3-hydroxy-2-methyl propionic acid with A. pasteurianus with 97% e.e. and 100% molar conversion [113], 

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Biocatalytic Asymmetric Oxidations with Other Enzymes... 

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