Biocatalysis deracemization

An emerging technique that takes advantage of the compatibility of aqueous chemistry and biocatalysis is the use of in situ reactions to promote deracemizations or DKRs.31 For example, reductive... 

Pamies, O., and Backvall, J. E. 2003b. Combined metal catalysis and biocatalysis for an efficient deracemization process. Curr. Op. Biotechnol., 74(4) 407-413. 

Simeo Y, KrontU W, Paber K. Biocatalytic deracemization dynamic resolution, stereoinversion, enantioconvergent processes, and cyclic deracemization. In Biocatalysis in the Pharmaceutical and Biotechnology Industries, Ed. Patel RN. CRC Press, Boca Raton, PL, 2007, p. 27. 

Deracemization products by biocatalysis are listed in Figure 33.9, and the mechanisms is shown in Scheme 33.21. If the (5)-specific enzyme catalyzed reversible transformation of (S)-alcohol to ketones and ketones to (S)-alcohol, and the reaction catalyzed by (/f)-specific enzyme is irreversible, (/ )-alcohol accumulated. 

Tessaro D, Molla G, Pollegioni L, Servi S. Chemo-enzy-matic deracemization methods. In Fessner W-D, Anthon-sen T, editors. Modern biocatalysis stereoselective and environmentally friendly reactions. Weinheim Wiley-VCH 2009. p 195-228. 

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