Bioassays for Toxicity of Mixtures

Organic Pollutants An Ecotoxicological Perspective, Second Edition 

Fish hepatocyte lines have also been developed, which can show cytochrome P450 lAl induction due to PAHs and planar polychlorinated aromatic compounds binding to the Ah receptor (Vaillant et al. 1989, Pesonen et al. 1992). 

Apart from the scientific advantages offered by this new technology, it has also been welcomed by organizations seeking a reduction in the number of animals used in toxicity testing (see Chapter 15, Section 15.6, and Walker 1998b). 

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