Bioactivity potency

Substructure and keyword searches including bioactivity, potency and selectivity data, structure-activity relationships, pattern recognition, Boolean searches, and modeling... 

Bioactivity potency of lycopene is dependent on the extent of degradation due to isomerization and oxidation. The main causes of lycopene degradation during food processing are oxidation and isomerization. Determination of the extent of lycopene isomerization would provide better insights into the potential health benefits of processed food products. In processed foods, oxidation is a complex process and depends upon many factors, such as processing conditions, moisture, temperature, and the presence of pro- or antioxidants and of lipids. The characterization and quantification of isomers would be desirable to more accurately assess the bioactivity than just the total lycopene content with no knowledge of its isomeric composition. 

Bioactivity potency depends on the content of total lycopene and the extent of isomerization 4,5,14,18). Thus isomerization would lead to change the bioactivity of lycopene. Characterization and quantification of lycopene isomers... 

Potency of hGH preparations is quantitatively deterrnined, in terms of mass per vial, by one or more chromatographic procedures (50). Biopotency is calculated from the mass-based potency using a conversion factor, typically 3 lU/mg. Traditionally a bioactivity assay using hypophysectomized rats has been used to determine potency however, the imprecision of this assay has resulted in its use only as a semiquantitative indicator of bioactivity (1), sometimes referred to as a bioidentity test. 

Bioactive compounds, such as carotenoids have strong antioxidative properties and are used as efficient radical scavengers. In some natural sources several carotenoid isomers can be found, which differ in their biochemical activities such as bioavailability or antioxidation potency. Knowing the structure and concentration of each stereoisomer is crucial for an understanding of the effectiveness... 

Compounds 13-18 were tested for acetylcholinesterase inhibition activity and it was found that compounds 13 and 14 exhibited acetylchohnesterase inhibition activity with IC values (inhibition of enzyme activity by 50%) of 17 and 13 pM, respectively. Compounds 15-18 showed moderate enzyme inhibition activity with ICj, values of 35, 80, 76, and 100 pM, respectively. This bioactivity data suggested that the higher enzyme inhibition potency of compounds 13 and 14 may hypothesized due to the presence of a tetrahydrofuran ring incorporated in their stractures. Fnrthermore, compounds 1 and 2 exhibited nearly the same bioactivity and this indicated that C-7 hydroxyl group does not play any role in enzyme inhibition activity. 

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