Bioactivity of Related Compounds

These products exhibited a wide variety of biological activities ranging from very specific, particularly when utilizing synthetic alcohol-containing reactants such as poly(vinyl alcohol), to very broad ranging, particularly when employing natural alcohol-containing reactants such as sucrose, dextran, cellulose, and xylan (see, e.g.. Refs. 39, 40). 

A basic mechanism that is believed to be responsible for this difference in activity involves release of the organotin. In cases where the comonomer is biologically active, release of the comonomer drug occurred through either simple physical hydrolysis or through hydrolysis initiated or is assisted by hydrolyzing enzymes emitted by the particular microorganism. It is uncertain if the polymer, some 

As noted before, Carraher has previously reported the synthesis of organotin polyethers and organotin polyamines. The synthesis of similar materials is reported here except that they are based on the amino alcohol-containing reactant acyclovir. The product will have the following general repeat unit (6)  

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