Bioactive terpenes from Wieland Miescher keton

SYNTHESIS OF BIOACTIVE TERPENES FROM WIELAND-MIESCHER KETONE AND ITS METHYL... 

ABSTRACT The Wieland-Miescher ketone (1) and its methyl analog (2) have been utilized for the synthesis of several sesquiterpenes like warburganal, muzigadial, albicanol, etc. Similarly several bioactive diterpenes like taxodione, pisiferic acid, aphidicolin, etc., have been synthesized from these ketones. The utility of several reagents in the total synthesis of terpenoid compounds has been documented. The developments of several routes for a single terpene from these ketones have been discussed. 

The Wieland-Miescher ketone (1) can be commercially obtained or prepared [1,2] in the laboratory. Its methyl analog (2) is probably not commercially available but can be prepared in the laboratory by the published procedure [3,4]. The aim of the present review is to describe briefly the synthesis of several bioactive terpenes from these ketones (1) and (2). It describes only the synthesis (total and formal) of bioactive di-and sesquiterpenes. It is necessary to mention that the review does not claim to include the synthesis of all bioactive terpenes from the above mentioned ketones. 

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See also in sourсe #XX -- [ ]

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