Bioactive secondary metabolite from Okinawan sponge

BIOACTIVE SECONDARY METABOLITES FROM OKINAWAN SPONGES AND TUNICATES... [Pg.185]

Bioactive Secondary Metabolites from Okinawan Sponges and Tunicates... [Pg.920]

ABSTRACT Marine invertebrates such as ascidians, sponges and others are a prolific source of bioactive secondary metabolites. We have isolated a variety of marine natural products from the Okinawan marine invertebrates by using the sea urchin egg assay. Our recent work, the isolation, structure determination and activities of chlorinated macrolides, sesterterpenic acids, a bromotyrosine derivative, acetogenin derived endoperoxides, diterpene alkaloids, sesquiterpene quinones and spiro-sesquiterpenes, is presented in this article. The syntheses of these metabolites are also described. [Pg.57]