Binding-site barrier

Fujimori, K., D.G. Coveil, IE. Fletcher, and IN. Weinstein, A modeling analysis of monoclonal antibody percolation through tumors a binding-site barrier. I Nucl Med, 1990.31(7) 1191-8. 

Juweid, M., Neumann, R., Paik, C., Perez-Bacete, M.J., Sato, J., van Osdol, W. et al. (1992) Micropharmacology of monoclonal antibodies in solid tumors direct experimental evidence for a binding site barrier. Cancer Res., 52, 5144-5153. 

Saga, T., Neumann, R.D., Heya, T., Sato, J., Kinuya, S., Le, N., et al. (1995) Targeting cancer micrometastases with monoclonal antibodies a binding-site barrier. Proc. Nat. Acad. Sci. USA, 92, 8999-9003. 

As defined in Fig. BA, the quantity 2d in Equation 4 is the total length from one side to the other of the channel and at is the distance from the binding site to the central barrier. 

Geldenhuys WJ, Lockman PR, McAfee JH, Fitzpatrick KT, Van der Schyf CJ and Allen DD. Molecular modeling studies on the active binding site of the blood-brain barrier choline transporter. Bioorg Med Chem Lett 2004 14 3085-92. 

The mechanism involves a metal atom insertion into the O—H bond, thus resulting in the formation of an adsorbed metal—OH species (at the same or similar binding site) and a new metal—H bond. This is a classic bond activation process, which involves a significant stretch of the O—H bond in order to lower the antibonding ooh orbital to enable it to accept electron density from the metal. The reaction has been calculated by DFT to be endothermic by +90 kJ/mol over Pt(lll) surfaces with an activation barrier of +130 kJ/mol [Desai et al., 2003b]. 

Although the mucus layer acts as a barrier to some invading pathogens, it also supports the growth and maintenance of a number of commensal bacteria in the GIT. It acts as an initial binding site, a source of nutrients for growth, and is a niche where these bacteria can replicate and potentially compete with other newly introduced bacteria (Laux et ah, 2005). Therefore, tissues that produce mucus have the potential to provide the host... 

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