Binding of Platinum—Amine Complexes

Effect of amines and platinum—amine complexes on melting temperature, (T ), of calf-thymus DNA. 

The luminescent properties of platinum-modified DNA have also been studied, the fluorescence being quenched and phosphorescence enhanced [111]. Raman difference spectroscopy has shown that some loss of B conformation occurs on binding [124]. Competition studies with polynucleotides, using this technique confirmed the kinetic preference for guanine binding [125]. Changes in the NMR of platinated DNA show distinctive shifts, different from those obtained with intercalators [126]. 

---