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Binding mode ethidium bromide

The interactions of several phenothiazine drugs with DNA were studied by electronic absorption and fluorescence spectra, using ethidium bromide (EB) as a probe. According to the results, both CPZ-HC1 and TFZ-HC1 could intercalate into DNA, but promethazine-HCl, which possesses a similar alkyldimethylamino group to CPZ, could weakly bind to DNA by mixed modes. These interactions could be inhibited at high ionic concentrations [160]. [Pg.210]

There are numerous probes available that spontaneously bind to DNA, displaying enhanced emission. Ethidium bromide weakly fluoresces in water, but this intensity is greatly increased upon binding to DNA (Fig. 5). The mode of binding is due to the intercalation of the planar aromatic ring between base pairs of doublehelical DNA. Acridine orange also binds to... [Pg.1233]

See other pages where Binding mode ethidium bromide is mentioned: [Pg.217]    [Pg.92]    [Pg.44]    [Pg.521]    [Pg.189]    [Pg.58]    [Pg.56]    [Pg.112]    [Pg.58]    [Pg.137]    [Pg.1386]    [Pg.414]    [Pg.173]    [Pg.163]    [Pg.171]    [Pg.192]    [Pg.316]   
See also in sourсe #XX -- [ Pg.56 , Pg.57 , Pg.58 , Pg.59 , Pg.60 , Pg.61 ]



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