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Binding by macromolecules

Surfactants. The use of surfactants is greatly restricted in formulating ophthalmic solutions. The order of surfactant toxicity is anionic > cationic >> nonionic. Several nonionic surfactants are used in relatively low concentrations to aid in dispersing steroids in suspensions and to achieve or to improve solution clarity. Those principally used are the sorbitan ether esters of oleic acid (Polysorbate or Tween 20 and 80), polymers of oxyethylated octyl phenol (Tyloxapol), and polyoxyl 40 stearate. The lowest concentration possible is used to perform the desired function. Their effect on preservative efficacy and their possible binding by macromolecules must be taken into account, as well as their effect on ocular irritation. The use of surfactants as cosolvents for an ophthalmic solution of chloramphenicol has been described [271]. This com-... [Pg.458]

See other pages where Binding by macromolecules is mentioned: [Pg.243]    [Pg.243]    [Pg.249]   
See also in sourсe #XX -- [ Pg.327 , Pg.328 , Pg.329 ]

See also in sourсe #XX -- [ Pg.327 , Pg.328 , Pg.329 ]

See also in sourсe #XX -- [ Pg.327 , Pg.328 , Pg.329 ]

See also in sourсe #XX -- [ Pg.327 , Pg.328 , Pg.329 ]



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Macromolecules binding

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