Binding and Dynamic Aspects of Metallothionein Structure

Metal Binding and Dynamic Aspects of Metallothionein Structure 

In most of the mammalian tissues studied, there are two major isoforms of MT (termed MT-1 and MT-2), which differ slightly in amino acid sequence and net charge. These MT isoforms bind metals identically but are encoded by two distinct genes. Recently two other mammalian MT genes (termed MT-3 and MT-4) have been identified in certain mammal tissues (Palmiter et al. 1993), but their significance is not yet understood. In contrast, only one MT gene has been isolated from avian species, chicken, and turkey (Fernando and Andrews 1989). 

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B. Metal Binding and Dynamic Aspects of Metallothionein Structure... 

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