Cerebrotendinous xanthomatosis bile alcohols

Structure and Biosynthesis of Bile Alcohols Disorders of Cholesterol Side-Chain Oxidation in Cerebrotendinous Xanthomatosis... 

Isolation and Characterization of Bile Alcohols in Cerebrotendinous Xanthomatosis ( CTX1... 

Dayal, B., Salen, G., Tint, G. S., Toome, V., Shefer, S., and Mosbach, E.H. (1978). Absolute configuration of pentahydroxy bile alcohols excreted by patients with cerebrotendinous xanthomatosis a circular dichroism study. J. Lipid Res. 19 187-190. 

Shimazu, K., Kuwabara, M., Yoshi, M., Kihira, K., Takeuchi, H., Nakano, I., Ozawa, S., Onuki, M., Hatta, Y., and Hoshita, T. (1986). Bile alcohol profiles in bile, urine, and feces of a patient with cerebrotendinous xanthomatosis. J. Biochem. (Tokyo) 99 477-483. 

Batta, A. K., Shefer, S., Batta, M., and Salen, G. (1985). Effect of chenodeoxycholic acid on biliary and urinary bile acids and bile alcohols in cerebrotendinous xanthomatosis monitoring by high performance liquid chromatography. J. Lipid Res. 26 690-698. 

In 1974, Setoguchi et al. found that patients with cerebrotendinous xanthomatosis had an impaired sjTithesis of bile acids and excreted large amounts of C27 bile alcohols in bile and feces [76]. Since then, a number of investigations have revealed the occurrence of bile alcohols in mammals. It is now recognized that, when new analytical methods are applied, traces of bile alcohols can be detected even in biological fluids from healthy humans. Table 3 lists all the known bile alcohols identified in mammals. 

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