Biguanides lactate production

Marroquin, L.D., dykens, J.D., Nadanadva, S Jamieson, J. and Will, Y. (2008) Biguanide-induced mitochondrial dysfunction increases lactate production and reduces viability of aerobically poised HepG2 and human hepatocytes in culture. The Toxicologist, 2008, 903. 

Mechanism and susceptibility factors Biguanides in high doses inhibit the oxidation of carbohydrate substrates by affecting mitochondrial function. Anoxidative carbohydrate metabolism stimulates the production of lactate. High lactate production leads to lactic acidosis (type B) with a low pH (<6.95). Hyperlactatemia was common in patients taking buformin, even without alcoholism or impaired liver, kidney, or cardiac function (70). 

Dykens JA, Jamieson J, Matroquin L, Nadanaciva S, Billis PA, Will Y (2008a) Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro. Toxicol Appl Pharmacol 233, 203-10. 

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