2-Bicyclo hexyl derivatives, products

SCHEME 8. A comparison of the products of hydrolysis of different 2-bicyclo[3.1.0]hexyl derivatives under various conditions... 

Several tricyclic systems which are not usually treated as 2-bicyclo[3.1.0]hexyl derivatives, but which should be included in this section are as follows. TTie solvolyses of the exo and endo tricyclo[3.3.0.0 ]oct-3-yl p-nitrobenzoates (63 and 64) were examined by Johnson and coworkers in 70% aqueous acetone at 100°C. The relative rates and products of reaction are given in Scheme 12. It is seen that with the exception of higher endo-product selectivity, the behavior of this system is similar to that for the parent system. 

Studies of the rates and products of hydrolysis of ewJo-and exo-2-bicyclo[4.1.0]heptyl derivatives 75 and 76 were first reported in preliminary form by Goering and Rubenstein and later in more detail by othersThe relative rates below for reactions in 80% aqueous acetone at 80°C reveal that as with the 2-bicyclo[3.1.0]hexyl system (fc[4.1.0] = ca.l50/c[3.1.0]) reaction rates are essentially independent of leaving group geometry. This indicates that both exo and endo isomers can ionize through bisected... 

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