Bicyclic homologue

The strained c ,traws-l,3-cyclooctadiene 1 cyclizes quantitatively at 80 °C to the bicy-clo[4.2.0]octene 2 (equation 3). The higher homologue 3 exists in equilibrium with the bicyclic isomer 4 above 175 °C (equation 4)4. 

The flash vacuum pyrolysis of isopropylidene (1-ally 1-1-azacycloalk-2-ylidene)malonate (1277) at 460-680°C and 10 5-10 3 torr yielded a mixture of bicyclic azepines (1278) and pyrrolinones (1279) (85TL833) (Scheme 53). The ratio of 1278 and 1279 shifted towards the lower homologue (1279) at higher reaction temperature. 

Isoprenyi glyceryl ethers archaeol-like (archaeol Cm-C ), comprising C20-C25 and C25"C25 homologues (an extreme halophilic, thermoacidophilic, and methanogenic Archaea Kates 1993 caldarchaeol-like (caldarchaeol monocyclic C o-C ), comprising bicyclic structures from thermoacidophilic and methanogenic Archaea Kates 1993. (Archaea in bold ce are not meant to be exclusively marine). 

The oxidation of 2-iodo-l,3-benzenedicarboxylic acid (25) with peracetic acid gives very stable bicyclic iodinane (26) (65TL2681). The homologue, 2-iodo-l,3-bis(carboxy-... 

The 3-chloromethyl cephalosporin 41 has been used for the preparation of nitrocefin 42 via Finkelstein and Wittig reactions <05JOC367>. The bicyclic P-lactam 43, a simple C3 homologue of sulbactam, has been prepared and evaluated as an improved inhibitor of class C P-lactamases <05JOC4510>. 

This method may be used in the case of aliphatic methyl ketones which give, under acidic conditions, the products of aldol condensation, while higher homologues require a very long tirne . N-Methylation of dihydroisoquinolines [32, R = H, Ph, R = R = Me R = H,R = Me,R = Et R R = (CH2)s] with methyl iodide gave enamines JJ186 bicyclic enamine 34 has been prepared by alkylation of the imine 35 followed by treatment of the iminium salt with base . ... 

Enamines reaction with methanesulphonyl chloride and its homologues in the presence of triethylamine to yield thietane 1,1-dioxides. Thus 1-morphoIinocyclohexene gives a bicyclic thietane dioxide and 2-methyl-l-pyrrolidinopropene and other enamines derived from aliphatic aldehydes react analogously (equation 1). It is thought that the reactions proceed by way of the unisolable sulphene 1, which adds to the enamine double bond in a stepwise or concerted manner. This question has been much debated (for a critical discussion, see Reference 2, p. 3386) and will not be pursued here. It has been found that there is a lack of stereoselectivity in the addition of sulphene to the conformationally rigid enamines derived from 4-t-butylcyclohexanone . 

The bicyclic imide (32) reacted under vigorous conditions with stable ylides to give mixtures of the mono- and bis-olefins. The homologue (33) behaved similarly but no reaction was observed with (34). The sulphon-amide (35) reacted normally under vigorous conditions. 

CjjHjjNO, Mr 209.33, [a] -13 (CHCI,), cryst., mp. 204-205 °C (hydrochloride). Bicyclic alkaloid from ladybird beetles of the genus Adalia. It is biosynthet-ically related to coccinelline, the major alkaloid of ladybird beetles. Homologues of A. have been identified in Euphorbia plants. 

Bicyclic acetals are obtained in the cyclization of alkenyl diols as shown in Scheme 31, where the attack of OH group toward an internal alkene formed after the oxypalladation process takes place.f " " Thus, optically active natural (5)-(-)-frontaUnt" m43] prepared from (5)-6,7-dihydroxy-6-methyl-l-heptene. Amberketal and its homologue are able to be similarly synthesized,... 

Finnish turpentine oil closely resembles Eussian oil. Aschan > has identified it in the following compounds diacetyl, furane, methyl-furane, methyl-isobutyrate, benzene and its homologues, pinene, sylvestrene, 1-limonene, and dipentene. He has also recently isolated a new terpene from this oU, boiling at 163 to 165 , specific gravity 0 8628 at 20 , and specific rotation -H 7 7 . It is a saturated bicyclic terpene, closely related to... 

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