Biased diversity

INFORMATION-BIASED - DIVERSITY-BASED - TESTED ON MANY TARGETS - DESIRED OUTCOME VALUABLE HIT... 

Table 3 Highest Scoring 25 Designs from the Series of 432 Biased Diversity Substituent Sets from Table 2 ...

An animal s needs for stimulus diversity are difficult both to define and quantify (Carlstead 1996). Enrichment is often anthropomorphically rather than ecologically relevant (Chamove 1989), and due to human sensory biases we may fail to realize the importance of olfaction to less charismatic species, or those species with lower perceived levels of olfactory awareness (Hancox 1990 Somerville and Broom 1998). 

The 5 k actives with percent inhibition of 25 to 40% and that feU into clusters of less than five compounds were treated separately using BCUT diversity analysis, as described in Section 6.2.5. A cell-based selection biased by primary activity from six bins per each of six axes yielded 1258 compounds. The combined selection from filtering, clustering, and diversity totaled 6986 compounds representing 3337 ring scaffolds and was submitted for confirmation assays. Note that the full set of 16 k filtered actives contained 9254 ring hashcodes, so the selected set covers 36.1% of the represented scaffolds. Because of the presence of duplicate samples in the corporate screening collection, 7275 samples were pulled and assayed. 

Diverse personal viewpoints enhance objectivity— As opposed to a single investigator, a team is less likely to he subjective or biased in its conclusions. A team s conclusions are more likely to be accepted by the organization. 

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