Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...

Articles Figures Tables About

Bevantolol

Bevantolol hydrochloride is a moderately lipophilic, long-acting, cardioselective -adrenoceptor blocker. It has no ISA but has membrane-stabilizing activity. The dmg is in use in Europe for the treatment of hypertension and angina. It is rapidly absorbed from the GI tract. Peak plasma levels occur in 1—2 h. It is metabolized extensively in the Hver to a metaboHte that has some ISA. It is excreted by the Hver and the kidneys and excretion is delayed in patients having kidney failure. [Pg.127]

Application of this scheme to o-cyclopentyl phenol, cyclohexylphenol and m-cresol thus leads to respectively, penbutolol (47), exapralol (48) and bevantolol (49)... [Pg.28]

C10H15NO2 120-20-7) see Benzquinamide Bevantolol Denopamine Dobutamine Dopamine Dopexamine Papaverine... [Pg.2359]

A -(2,3-epoxypropyl)phthalimide (CiiH NOj . 5455-9S-/) see Mosapride citrate 2,3-epoxypropyI m-tolyl ether (C,, H 202 2186-25-6) see Bevantolol Toliproiol (2,3-epoxypropyl)trimethylaminonium chloride (CjH,4C1NO 3033-77-0) see Carnitine (2a,3a,5a,16P,17p)-2,3-epoxy-16-(l-pyrrolidinyl)andro-stan-17-ol... [Pg.2372]

To a suitable reactor under a nitrogen blanket is added 13.7 kg of p-(3,4-dimethoxyphenyl)ethylamine. The amine is cooled to 5°C and 12.5 kg of 3-(m-tolyloxy)-l,2-epoxypropane is added maintaining the temperature between 5-10°C. After 10 hours, the mixture is seeded with bevantolol free base seeding is repeated approximately every 2 hours until it is evident that crystallization has started. After stirring for 48 hours at 10°C, 26 L of hexane is added. The temperature is raised to 25°C and stirring is continued for 48 hours. The slurry is filtered and the collected solid is dried under vacuum. The product is dissolved in 60 L of isopropyl alcohol and the solution is filtered. [Pg.619]

The reactor and filter are rinsed with 186 L of isopropyl alcohol and 2.7 kg of anhydrous hydrogen chloride is added to the combined filtrate. The batch is heated to reflux for 2 hours. The temperature is adjusted to 65°C and the solution is seeded with bevantolol hydrochloride crystals. The mixture is held at this temperature with stirring until a heavy sand-like slurry is present. The mixture is allowed to cool to ambient temperature without stirring or artificial cooling. It is then cooled to 20°C. The slurry is centrifuged and the product rinsed with isopropyl alcohol until the filtrate is colorless. After being vacuum dried at 50-55°C the product is milled if necessary yield of bevantolol hydrochloride 22.7 kg (78.6%) melting point 137-138°C. [Pg.619]

See other pages where Bevantolol is mentioned: [Pg.105]    [Pg.124]    [Pg.256]    [Pg.263]    [Pg.233]    [Pg.238]    [Pg.238]    [Pg.2337]    [Pg.2371]    [Pg.2419]    [Pg.444]    [Pg.583]    [Pg.608]    [Pg.585]    [Pg.610]    [Pg.1305]    [Pg.1581]    [Pg.326]    [Pg.105]    [Pg.618]    [Pg.618]    [Pg.618]    [Pg.619]    [Pg.619]    [Pg.619]    [Pg.238]    [Pg.238]    [Pg.238]    [Pg.2337]    [Pg.2371]    [Pg.2419]    [Pg.196]   
See also in sourсe #XX -- [ Pg.28 ]

See also in sourсe #XX -- [ Pg.3 , Pg.28 ]

See also in sourсe #XX -- [ Pg.323 ]

See also in sourсe #XX -- [ Pg.238 ]

See also in sourсe #XX -- [ Pg.196 , Pg.225 ]

See also in sourсe #XX -- [ Pg.83 ]

See also in sourсe #XX -- [ Pg.107 ]

See also in sourсe #XX -- [ Pg.176 ]

See also in sourсe #XX -- [ Pg.730 ]

See also in sourсe #XX -- [ Pg.226 ]



SEARCH



Bevantolol hydrochloride

© 2024 chempedia.info