Bepridil adverse effects

T effects OF amiodarone, astemizole, atorvastadn, barbiturates, bepridil, bupropion, cerivastatin, cisapride, clorazepate, clozapine, clarithromycin, desipramine, diazepam, encainide, ergot alkaloids, estazolam, flecainide, flurazepam, indinavir, ketoconazole, lovastatin, meperidine, midazolam, nelfinavir, phenytoin, pimozide, piroxicam, propafenone, propoxyphene, quinidine, rifabutin, saquinavir, sildenafil, simvastatin, SSRIs, TCAs, terfenadine, triazolam, troleandomycin, zolpidem X effects W/ barbiturates, carbamazepine, phenytoin, rifabutin, rifampin, St. John s wort, tobacco X effects OF didanosine, hypnotics, methadone, OCPs, sedatives, theophylline, warfarin EMS T Effects of amiodarone, diazepam, midazolam and BBs, may need X- doses concurrent use of Viagra-type drugs can lead to hypotension X- effects of warfarin concurrent EtOH use can T adverse effects T glucose ODs May cause an extension of adverse SEs symptomatic and supportive Rivasrigmine (Exelon) [Cholinesterase Inhibitor/Anri ... 

The main adverse effect of bepridil is torsade de pointes due to QT interval prolongation. After intravenous infusion bepridil can cause local reactions (3) and phlebothrombosis (4). Other minor adverse effects that have been reported include urticaria (5), gastrointestinal disturbances (especially diarrhea) (6,7), and dizziness (6-8). Hepatic enzymes can rise (9,10). 

What adverse effects might result from bepridil administration that are related to its effect on the cardiac action potential ... 

E. Toxicity The calcium channel blockers cause constipation, edema, nausea, flushing, and dizziness. More serious adverse effects include congestive heart failure, atrioventricular blockade, and sinus node depression these are more common with verapamil than with the dihydropyridines. Bepridil may induce torsade de pointes and other arrhythmias. 

---