Bephenium salts

The starting material for bephenium salts is 2-phenoxyethyl bromide (42), which may be converted into bephenium either in one or two steps as shown in scheme 2 [4-9]. 

Bephenium Bephenium, 3-hydroxy-2-naphthoat benzyldimethyl(2-phenoxyethyl) ammonia (38.1.37), is made by reacting the sodium salt of 3-hydroxy-2-naphthoic acid with benzyldimethyl(2-phenoxyethyl)ammonia chloride (38.1.36). This is in turn made from benzyl chloride and Af-(2-phenoxyethyl)dimethylamine (38.1.35), which is synthesized by reacting sodium phenolate with 2-dimethylaminoethylchloride [41,42]. 

High molecular weight quaternary salts such as bephenium hydroxynaphthoate (XXI) and pyrvinium embonate (XXII), being quaternary, have low lipid solubility but also have... 

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