Benzylpenicillin penicillin applications

Many of the medical products reviewed here find multiple applications. Thus procaine compounded with benzylpenicillin, penicillin G is an antimicrobial veterinary drug, approved in the US as a postexposure prophylaxis following inhalation of anthrax, providing that the strains do not have penicillin resistance. 

The determination of total penicillins is not easy. The U,S.P. uses the direct iodimetric assay as applied to benzylpenicillin after dissolving the sample in methanol, but this may lead to results which are 3 to 5 per cent low, due to interaction of procaine with iodine. Wild suggested the use of silicotungstate as a procaine precipitant before application of the iodimetric method but details given in his method required clarification. Based on the original, the following modification has been found by us to be satisfactory. 

We also present a quantitative determination in solid binary mixtures of three penicillin antibiotics benzylpenicillin, bacampicillin, and amoxicillin. The method appears to be unique, contrasting with the known vibrational approaches in solution, where the Raman method has been used. In the solid state, some penicillin antibiotics give a broad fluorescence band, which overlaps the Raman peaks and limits its application for quantitative analysis in solid state. Using our... 

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