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Benzylisoquinoline alkaloids enzymology

As another example of the value of enzymological studies, the major enzymes of the benzylisoquinoline alkaloid pathway have also been isolated from plant tissue culture and studied by Zenk and co-workers (see Chapter 34) (Fig. 1.2). An enzyme, (S)-norlaudanosoline synthase, which catalyzes the conversion of dopamine and (3,4-dihydroxyphen-yl)acetaldehyde (9) into (S)-norlaudanosoline (10) has been purified about 40-fold from cell suspension cultures of Eschscholtzia tenuifolia (see also cluster 32 for up-dated in-... [Pg.2]

Zenk, M. H., Enzymology of benzylisoquinoline alkaloid formation, in The Chemistry and Biology of Isoquinoline Alkaloids (J. D. Phillipson, M. F. Roberts, and M. H. Zenk, eds.), 241-256, Springer-Verlag, Berlin, 1985. [Pg.616]


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