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Benzyl Meldrum intramolecular Friedel-Crafts acylation

Pillion, E. and Fishlock, D. 2003. Convenient access to polysubstituted 1-indanones by Sc(OXf)3-catalyzed intramolecular Friedel-Crafts acylation of benzyl Meldrum s acid derivatives. Org. Lett. 5 4653 656. [Pg.30]

Intramolecular Friedel-Crafts acylation of enolizable benzyl Meldrum acids 22 wifh scandium triflate (7%-12% mol) in refluxing nitromethane or acetonitrile is a powerful tool for the preparation of a variety of indan-l-ones 23 (Table Meldrum acid derivatives, mono- and dis-... [Pg.46]

The intramolecular Friedel-Crafts acylation of benzyl Meldrum s acids was catalyzed by Sc(OTf)3 under mild conditions (Scheme 12.25) [54]. Depending on the substituents of the benzyl Meldrum s acids, yields of 1-indanones ranged from 13 to 83%. [Pg.71]


See also in sourсe #XX -- [ Pg.46 ]




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Acylation intramolecular

Benzyl Meldrum intramolecular

Benzyl intramolecular

Friedel acylation

Friedel intramolecular

Friedel-Crafts acylation intramolecular

Friedel-Crafts benzylation

Friedel-Crafts benzylations

Intramolecular -acyl

Intramolecular Friedel-Crafts

Meldrum intramolecular Friedel-Crafts

Meldrum intramolecular Friedel-Crafts acylation

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