Benzyl Meldrum intramolecular

Pillion, E. and Fishlock, D. 2003. Convenient access to polysubstituted 1-indanones by Sc(OXf)3-catalyzed intramolecular Friedel-Crafts acylation of benzyl Meldrum s acid derivatives. Org. Lett. 5 4653 656. 

Intramolecular Friedel-Crafts acylation of enolizable benzyl Meldrum acids 22 wifh scandium triflate (7%-12% mol) in refluxing nitromethane or acetonitrile is a powerful tool for the preparation of a variety of indan-l-ones 23 (Table Meldrum acid derivatives, mono- and dis-... 

The intramolecular Friedel-Crafts acylation of benzyl Meldrum s acids was catalyzed by Sc(OTf)3 under mild conditions (Scheme 12.25) [54]. Depending on the substituents of the benzyl Meldrum s acids, yields of 1-indanones ranged from 13 to 83%. 

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