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Benzyl 4,4-dimethyl-2,6-dioxocyclohexylidene

A-[l-(4,4-Dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]amino benzyl (Dmab) Ester ... [Pg.427]

Dmab 4- A-[ 1 -(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl] amino benzyl... [Pg.795]

The 4-[/V-(l-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl)amino]-benzyl (ODmab) esters display complete stability to 20% v/v piperidine in DMF and acidolysis (TFA), yet are readily removed with 2% v/v hydrazine monohydrate in DMF within minutes. However, it should be noted that this deprotection condition is sufficient to remove the A-Fmoc protecting group. Nevertheless, the ODmab ester has distinct advantages over OTmse and allyl esters, since its removal is facile (90, 91) and avoids extensive post-column manipulations. In a manner similar to the allyl ester technique (92), ODmab ester removal can be automated for convenience. It should, however, be... [Pg.174]

See other pages where Benzyl 4,4-dimethyl-2,6-dioxocyclohexylidene is mentioned: [Pg.371]    [Pg.677]    [Pg.250]    [Pg.298]    [Pg.213]    [Pg.41]    [Pg.219]    [Pg.429]    [Pg.376]   


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Benzyl-dimethyl

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