2- Benzoyl-3-morpholino

The thermolysis of 4-azidophenyl methyl ketone in morpholine at 170°C yields a mixture of the expected 5-acetyl-2-morpholino-3f/-azepine (33) and 6-acetyl-2-morpholino-3//-azepine (34), the product of a unique and totally unexpected thermal rearrangement of the 5-acetyl derivative.119 Similar results can be obtained in hot piperidine, whereas thermolysis of 4-azido-diphenyl ketone under similar conditions yields only the 6-benzoyl-2-(cycloalkylamino)-3//-azepines (7-18%) accompanied by much tar. 

Quinoxalines with a cychc substituent other than an unsubstituted cycloalkyl, morpholino, phenyl, or piperidino group Quinoxalines bearing a substituent with more than six carbon atoms, except for an unsubstituted benzyl or benzoyl group Quinoxalines with two or more independent functional groups on a single substituent... 

The syntheses shown in Scheme 26 (71CB1573) are based on dibenzo-/3-tropolone (108) and its enamines. Condensation of 108 and benzoin in the presence of ammonia affords pyrrole 109. The morpholino enamine gives pyrazole 110 via benzoylation, hydrolytic elimination of morpholine, and cyclization, whereas diazo-group transfer onto the anilino enamine leads to triazole 111. Dione 108 and p-nitrophenylazide in one step give predominantly the p-nitro derivative of 111 (92G249). 

Figure 14.6 Resonance stabilization of reactive intermediates from (i) bis(chloromethyl) ether, (ii) aliphatic nitrogen mustard, (iii) allyl chloride, (iv) benzyl chloride, (v) bis(morpholino)methane, (vi) benzoyl chloride, and (vii) dimethylcarbamyl chloride.

The addition reactions of aryl azides onto enamines bearing a carbonyl, sulfonyl, or nitro group in the 0 position with respect to the nitrogen atom have been investigated by Italian authors.240-241 The expected triazoline derivatives could not be isolated but were immediately converted into the corresponding 1,2,3-triazoles (49) and secondary amines. The reaction of p-nitrophenyl azide with l-benzoyl-2-morpholino-l-propene (48) is given as a typical example. 

Figure 3.84. Voxel obtained by irradiation of a mixed urethane acrylate oligomer and a urethane acrylate monomer in the presence of a mixture of benzoyl cyclohexanol and morpholino phenyl amino ketones at 780 nm using a 150-fs pulsed Ti sapphire mode-locked laser operating at 76 MHz, where light was focused by a 1.4 numerical aperture objective lens (a) scanning electronic microscopic images of the voxel and (b) longitudinal and lateral voxel size as function of the exposure time. (From Ref. [580] with permission of the American Institute of Physics.)...

Benzoyl-6-cyano-6-morpholino- 898 1,33-Triaza"bicyclo 3.3.0]octane... 

Benzoyl-2-morpholino-4-phenyl-l,3-thiazol768 Eine Mischung von 50 g (0,2 mol) l-(Benzoylamino-thio-carbonyl)-morpholin, 39,8 g (0,2 mol) aj-Brom-acetophenon und 50 ml Ethanol wird 5 min. unter RiickfluB erhitzt, mit 5 ml Triethylamin versetzt und nochmals 5 min. gekocht. Nach dem Abkiihlen verdiinnt man mit wenig Wasser und saugt das Endprodukt ab Ausbeute 33 g (94%) Schmp. 140-141" (Ethanol). 

Benzoyl-2,4-bis-[4-methoxy-phenyl]-l,3-thiazol(R =R2 = 4-OCHj—C6H5 R3 = CJ-I5)770 3,7 g (0,01 mol)4-Methoxy-N-(4-methoxy-a-morpholino-benzyliden)-thiobenzamidund 1,99 g(0,01 mol) oj-Brom-acetophe-non werden in 15 m/ Acetonitril gelost und anschlieBend mit 5 ml Triethylamin versetzt. Es wird kurz aufgekocht und nach dem Abkuhlen mit Wasscr vcrdunnt. Man saugt das farblose Endprodukt ab und kristallisiert aus Ethanol um Ausbeute 3,58 g (89%) Schmp. 149-150". 

BenZoylamino-thiocarbonyl)-ethoxycarbonyl-methyll-4-hydroxy- 8 2-Benzoyl-3-benzyl-5-ethoxycarbonyl-4-methyl-2,3-dihydro- 356 5-Benzoyl-2,4-bis-[4-methoxy-phcnyl]-aus 4-Methoxy-N-(4-methoxy-a-morpholino-bcnzyliden)-thio-benzamid und -Brom-aceto-phcnon 135 5-Benzoyl-2-chlor- 263... 

Benzoyl-2-(N-methyl-anilino)-4-methyl- 68 5-Benzoyl-4-methyl-2-(N-methyl-anilino)- 69, 134 5-Benzoyl-4-methyl-2-morpholino- 134 5-Benzoyl-4-methyl-2-piperidino- 134 5-Benzoyl-4-inethylthio-2-phenyl-... 

Morpholino- and Amino-Ketones These classes of photoinitiators present a good activity [Is], The cleavage mechanisms ((10.16) and (10.17)) and the reactivity of the excited states have been fully reported [2i,30], Excellent representatives of morpholino ketones are 2-methyl- l-(4-methylthiobenzoyl)-2-morpholino-propan-1-one TMPK (10.16) and 2-methyl-l-(benzoyl)-2-morpholino-propan-l-one MPK. In amino ketones, the introduction of a morpholino moiety on a benzoyl group such as in 2-benzyl-2(diethylamino)-4,-morpholinobutyrophenone MPPK (10.17) red shifts the absorption. In both cases, efficient initiating radicals are generated. 

The 5-benzoyl-2-(2-morpholino-l-phenylethenyl)thiazole (286) reacts with phenacyl bromide at 170-200°C to give the trisubstituted pyrrolo[2,l-Z>]thiazoles (287) (Equation (29)) <88EGP262863>. 

A soln. of benzoyl peroxide in anhydrous benzene added dropwise with icecooling at 0-4° during 45 min. to a stirred soln. of 1-morpholino-l-cyclohexene in the same solvent, stirring continued 30 min., aq. HGl added, and stirred 1 hr. at room temp. -> 2-henzoxy-l-cyclohexanone. Y 78%. S.-O. Lawesson, H. J. Jakohsen, and E. H. Larsen, Acta Ghem. Scand. 17, 1188 (1963). 

The carbonyl group contained in the initiators that were used, a mixture of benzoyl cyclohexanol and morpholino phenyl amino ketones (inset of Fig. 13a), exhibits two kinds of triplet states nn and nn. However, according to selection rules of electronic transition, transitions are symmetry forbidden and transition are symmetry allowed. Therefore the... 

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