Benzoxazepinones with phenols

Several biologically useful medium-sized benzo-fused heterocycles have been efficiently constructed by combining the efficiency of the Ugi condensation with a post-condensation S Ar cyclization, using an internal amino or hydroxyl nucleophile, and a nitrohalobenzoic acid 63 (Fig. 16). By introducing the additional nucleophile into the amine component, benzodiazepinones 79 [72], benzodiazoci-nones 80 [72], their benzo-fused counterparts 81 [72], benzoxazepinones 82 [72] and their fused counterparts 84 [60] and finally benzoxazocinones 83 [72] have been obtained. For the first two systems, the already described UDC strategy was exploited, whereas for the oxa heterocycles, the alcoholic or phenolic hydroxyl did... 

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