Benzothiophene carboxamides

A series of benzothiophene carboxamides, available from previous studies (IIIUBIIOI) were evaluated as analgesics and anti-inflammatory agents. Of these, N-benzyl-3-bromo-, 3-bromo-N-(4-fluorobenzyl)- and 3-bromo-N-(2-phenylethyl)-benzo[ ]thiophene-2-carboxamides attenuate nocipception and inflammation at lower concentrations than classical NSAIDs such as ibuprofen. These compounds are well tolerated and metabolized to avoid any toxicity... 

The class of benzothiophene-2-carboxamid-S,S-dioxides came to the attention of the Bayer research because of their in vitro antifungal activity against a broad range of agro- and material-protection relevant fungi (Elbe et al., 1992 Elbe et al., 1996). 

Table 2 Biological spectrum of Cyclohexyl-benzothiophen-2-carboxamid-S,S-dioxid (Preventol TP OC 3082) in ppm.

Kunisch, F., Kugler, M., Schrage, H., Elbe, H.-L., 1997. Benzothiophen-2-carboxamide-S,S-dioxides for use in Antifoulig Applications. WO 9711131. 

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