Benzophenone synthase from Centaurium erythraea

Previous researchers have suggested [6,8] that benzophenones are biosynthesized by condensation of metabolites from the shikimate pathway, forming the A-ring, and the acetate-malonate pathway, creating the B-ring. This produces the basic 13-carbon benzophenone skeleton, Fig. (1). Support for this biosynthetic pathway includes the isolation of benzophenone synthase from Centaurium erythraea [9] and research by Atkinson etal. [10] who examined benzophenones as intermediates in the synthesis of xanthones. (Xanthone biosynthesis is reviewed by... 

BEERHUES, L., Benzophenone synthase from cultured cells of Centaurium erythraea, FEBSLett., 1996,383,264-266. 

Further investigation of xanthone biosynthesis was carried out by Beer-hues with the detection of an enzyme named benzophenone synthase from cultured cells of Centaurium erythraea [34], The formation of 2,3, 4,6-tetrahydroxybenzophenone, which is a central step in xanthone biosynthesis, was shown in cell-free extracts from cultured cells of C. erythraea (Fig. 4). 

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