Benzodiazepines second-generation effects

Drugs that depress the CNS, such as the benzodiazepines, have their effects increased by interaction with the classic antihistamines. However, the second-generation antihistamines have not yet been proven to interact with CNS depressants such as alcohol or diazepam (34-37). 

Loprazolam mesylate is a potent hypnotic/sedative belonging to the second generation of annulated-1,4-benzodiazepines. The of loprazolam ( 6 hr.) is longer than those of triazolam and midazolam, but shorter than the "effective" TJs of flurazepam. 

---