Benzodiazepines quinazolinone synthesis

Zhang, W., Williams, J.P., Lu, Y., Nagashima, T., and Chu, Q. 2007. Fluorous synthesis of sclerotigenin-type benzodiazepine-quinazolinone library scaffold. Tetrahedron Letters, 48 563-65. 

Grieder and Thomas prepared a diverse library of natural product-like benzodiazepine-quinazolinone alkaloids similar to the family of circumdatins (Figure 11.72). Starting from benzodiazepinedione derivatives, the synthesis relied on a modified Eguchi protocol using a polymer-supported phosphine-mediated intramolecular aza-Wittig reaction in a key step of the reaction sequence. Following this route two sublibraries of tricyclic derivatives similar to the circumdatins D and E were prepared. 

W. Zhang, J.P. WUhams, Y. Lu, T. Nagashima, Q. Chu, Fluorous synthesis of sclerotigenin-type benzodiazepine-quinazolinones. Tetrahedron Lett. 48 (2007) 563-565. 

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