Busulfan Benzodiazepines

Drugs that may be affected by itraconazole include alfentanil, almotriptan, alprazolam, amphotericin B, aripiprazole, benzodiazepines, buspirone, busulfan, calcium blockers, carbamazepine, cilostazol, cisapride, corticosteroids, cyclosporine, digoxin, disopyramide, docetaxel, dofetilide, eletriptan, epierenone, ergot alkaloids, haloperidol, HMG-CoA reductase inhibitors, hydantoins (phenytoin), hypoglycemic agents, oral midazolam, phosphodiesterase type 5 inhibitors, pimozide, polyenes, protease inhibitors, quinidine, rifamycins, sirolimus, tacrolimus, tolterodine, triazolam, trimetrexate, vinca alkaloids, warfarin, and zolpidem. 

The authors of one study suggest that antiepileptics with fewer enzyme-inducing properties than phenytoin should he used as prophylaxis if busulfan is given for bone marrow transplant pretreatment. One UK manufacturer recommends prophylaxis with a benzodiazepine rather than phenytoin if high-dose busulfan is given. Clobazam , (p.619), has been suggested as a possible alternative to phenytoin. ... 

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