Benzo-l,2,4-thiadiazine 1,1-dioxide

Benzacridines, amino-, 408 Benzoic acids, o-(2-thenoyl)-, 66, 67 Benzol rlindolizines, 157-159 Benzopirridines, adduct with dimethyl acetylenedicarbo late, 144 Benzoquinoline, amino-, 408 Benzo[ ]quinol-4-one, 350 Benzo-l,2,4-thiadiazine 1,1-dioxides, 387 Benzothiazoles, amino-, 334 Benzo-l,2,4-triazin-3-one, 388 2,2 -Bithienyl, 56, 69, 74, 110, 118, 119 2,3 -Bithienyl, 56, 74 3,3 -Bithienyl, 23, 42, 75... 

Benzo[e]-l,2,4-thiadiazine 1,1-dioxide has been shown to prefer the AH-structure (432). A new, simple route to 3-oxo-derivatives of this system has been developed anilines are added to CSI (CSI is CISO2NCO) and the resultant N-chlorosulphonyl-ureas cyclized with AICI3. Yields are good to excellent, and... 

In Section II, the chemistry of 1,2,6-thiadiazine 1,1-dioxides and fused systems will be described, but no attempt has been made to cover all the literature dealing with benzothiadiazinones. Numerous derivatives related to the herbicide bentazone (3-isopropyI-lH-2,l,3-benzothiadiazin-4-one 2,2-dioxide) have been prepared and are described in various patents, which will not be included. The reactivity of bentazone and related 2,1,3-benzo-thiadiazinones has also been extensively studied (81AG(E)151). 

C15H9CI3N2O 13949-50-3) see Lorazepam 6-chloro-3-(chloromethyl)-3,4-dihydro-2/f-l,2,4-benzo-thiadiazine-7-sulfonamide 1,1-dioxide (CSH9CI2N3O4S2 1824-47-1) see Altizide 2-chloro-N-(2-chloro-6-methylphenyl)acetamide (C9H9CI2NO 6307-67-1) see Butanilicaine... 

Formal condensation of a benzene ring onto a 1,3,4-thiadiazine, a 1,2,4-thiadiazine, a 1,2,6-thiadiazine, or a 1,2,5-thiadiazine leads to the benzothiadiazine structures G-J. Two benzo derivatives of 1,2,3-thiadiazines are known 1,2,3-benzothiadiazine (K) and 3,1,2-benzothia-diazine (L). Both benzo derivatives occur mainly as, S,S-dioxides for review articles see refs 1 and 2. 

Chloro-3-(diehloromethyl)-3, 4-dihydro-2H-l, 2, 4-benzo-thiadiazine-7-sulphonamide 1, 1-dioxide 2H-1,2,4-Benzothiadiazine-7-sulphonamide, 6-ehloro-3-(dichloromethyl)-3,4-dihydro-1, 1-dioxide USP ... 

Y., Sekina, Y., and Hashimoto, M. Determination of 7-Chloro-3-(4-methyl-l-piperazinyl)-4H-1,2,4-benzo thiadiazine-1,1- dioxide (DU-717) in Plasma Using Electron-Capture Gas Chromatography J. Chromatogr. 160(1) 181-190 (1978) CA 90 80585r... 

A soln. of bromine in methanol added dropwise with stirring and cooling to a soln. of 5-nitro-2-p-chlorophenylthiobenzenesulfonamide in 5 NaOH 1-p-chlorophenyl-5-nitro-lH-l,3,2-benzodithiazole 3,3-dioxide. Y 92.1%.— The products may be regarded as cyclic sulfimides. F. e. and process modifications s. A. W. Wagner and R. Banholzer, B. 96, 1177 (1963) 3,4-dihydro-lH-l,2,4-benzo-thiadiazin-3-ones, in anhydrous medium, cf. A. 675, 189 (1964). 

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