Benzo antihistaminic

Loratadine (ll-[N-carboethoxy-4-piperidylidene]-8-chloro-6,ll-dihydro-5H-benzo-[5,6]-cyclohepta-[l,2-b]-pyridine) is an antihistamine. U.S. 4,282,233 (to Sobering) describes the preparation of the API and also gives recipes for syrup (Example 6) and tablet (Example 7) formulations. Estimate the cost of the making the API and both formulations. 

Multicyclic ring systems are also found to be present in synthetic heterocyclic pharmaceuticals. These drugs may be benzo derivatives of monocyclic heterocycles or they may contain other fused-on (said to be annelated or annulated) heterocyclic rings. An important example of a dibenzo derivative, namely, a derivative of the tricyclic phe-nothiazine ring system, is the valuable antihistamine methopromazine (9.142). Its synthesis employs conventional reactions of aromatic chemistry to constmct the interior thiazine ring, as is outlined in Scheme 9.84. 

Synonyms 4-(8-Chloro-5,6-dihydro-llH-benzo[5.6]cyclohepta[l.2-b]pyridin-l 1-ylidene)-l-piperidinecarboxylic acid ethyl ester Trade Names Clantin, Claritin, Clarityne, Lisino Use Antihistaminic... 

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