Benz acridine-5,6-epoxide

Mutagenicity data for benz[a]- and benz[c]acridine dlol epoxides and tetrahydroepoxldes reveals a deactivating effect of nitrogen dependent upon its position relative to the epoxide. Benz[a]acridine bay region dlol and tetrahydroepoxldes have significantly reduced mutagenicities relative to their... [Pg.69]

Benzacridine tetrahydroepoxides and did epoxides. The isosteric molecules BA, benz[a]acridine (BaAcr) and benz[c]acridine (BcAcr) and their derivatives provide excellent probes for studying the effect of electronic changes upon biological properties. The... [Pg.84]

Chang RJ, Levin W, Wood AW, Kumar S, Yagi H, Jerina DM, Lehr RE, Conney AH (1984) Tumorigenicity of dihydrodiols and diol-epoxides of benz[c] acridines in newborn mice. Cancer Res 44 5161-5164... [Pg.279]

Biological activation of polycyclic-hydrocarbon carcinogens proceeds through dihydrodiols and diol epoxides and such pathways are clearly possible for aza-aromatic compounds. To assist in investigating the existence of such routes, a range of dihydrodiols and diol epoxides of benz[c]acridine and benz[a]acridine (R.E. Lehr and S. Kumar, J. org. Chem., 1981, 367 ... [Pg.80]

A number of diol epoxides of benz [cj acridine have been prepared stereo-speciflcally eg. a- and 3- (81), and (82), which have been characterised by "bl mir". [Pg.16]

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