Benign prostatic hyperplasia urinary incontinence

Benign Prostatic Hyperplasia and Urinary Urge Incontinence... 

Blockade of alphai-adrenoceptors in the urinary tract leads to smooth muscle relaxation and improvement in urinary flow, and this pharmacological action has been used to ameliorate the urinary symptoms of benign prostatic hyperplasia. Prazosin can occasionally lead to urinary incontinence, particularly stress incontinence in women (1). 

Additional agents currently in development include drug (indication) (S)-doxazosin (benign prostatic hyperplasia) ( R, R)-formoterol (P2-agonist) (S)-fluoxetine (migraine prophylaxis) (5 -oxybutinin (urinary incontinence) (+)-norcisapride (nocturnal heartburn) (—)-pantopra-zole and (S)-lansoprazole (both are proton-pump inhibitors). 

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