Bekanamycin Sulfate

Chemical Name 2-Acetyl-7-(2-hydroxy-3-isopropylaminopropoxy)benzofuran Common Name — 

Chemical Name D-Streptamine, 0-3-amino 3 deoxy-a D glucopyranosyl-(1- 6)-0-[2,6 di-amlno-2,6 dideoxy-a D glucopyranosyl (1 4)]-2-deoxy sulfate (1 1) 

Trade Name Manufacturer Country Year Introduced 

200 liters of the medium containing 2.0% starch, 1.0% soybean meal,0.05% KCI,0.05% MgS04 7H20, 0.3% NaCI, 0.2% NaNOs was placed in the 400 liter fermenter, the pH was adjusted to 7.5, and the medium was then sterilized (pH after the sterilization was 7.0) for 30 minutes at 120°C, inoculated with 1,000 ml of 40 hour shake-cultured broth of S. kanamyceticus (a selected subculture of K2-J strain) and tank-cultured at 27°-29°C. As antifoam, soybean oil (0.04%) and silicone (0.04%) were added. The broth after 48 hours was found to contain 250 mcg/ml of kanamycin. 

A portion (950 ml) of the rich eluate was adjusted to pH 6.0 by the addition of sulfuric acid. Ultrawet K (7.0 g) In 70 ml water was added slowly to the neutralized eluate to precipitate kanamycin B dodecylbenzenesulfonate which was collected by filtration after adding filter-aid (Dicalite). The cake was washed with water and extracted with 100 ml methanol. After filtering and washing with methanol, sulfuric acid was added to the filtrate until no more kanamycin B sulfate precipitated. After addition of an equal volume of acetone to provide more complete precipitation, the kanamycin B sulfate was collected by filtration, washed with methanol and dried in vacuo at 50°C. 

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Streptomyces kanamycetius Bekanamycin sulfate Kanamycin sulfate Streptomyces layendulae Cycloserine... 

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