Beads-based sample enrichment

The importance for proteomic studies of being performed on standardized samples cannot be emphasized enough. Several approaches have been developed to address the problem of tissue heterogeneity. Beads-based sample enrichment (BBSE) and laser capture microdissection (LCM) procedures are emerging as the methods of choice. The aim of these procedures is to eliminate, as much as possible, all confounding and contaminating factors in order to obtain a sample quality that can be compared with cell lines without the disadvantages of in vitro cultures. 

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