Baylis-Hillman acetates alkylation with

Baylis-Hillman acetates have been conveniently transformed into tri/tetracyclic heterocyclic frameworks containing an azocine moiety via a one-pot multistep protocol involving alkylation, reduction, and cyclization sequence <2007OL2453>. Treatment of Baylis-Hillman acetate 284 with 1,3-cyclohexanedione in the presence of K2CC>3, followed by treatment of the resulting product with Fe/AcOH, gave 77% fused azocine 285 (Scheme 119). 

A rapid S allylic substitution of Baylis-Hillman acetates with ethyl(triphenyl phosphoranylidene) acetate was reported by Yadav et al. (2007) to give ethyl-5-aryl or alkyl-(E)-pent-4-enoates with high (E)-stereoselectivity under microwave irradiation. 

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