Basophil allergic inflammation initiation

Y Minegishi Y, Watanabe N, Karasuyama H 32 Basophils are essential initiators of a novel type of chronic allergic inflammation. Blood 2007 110 913- 33 920. 

Basophils Initiate IgE-Mediated Chronic Allergic Inflammation... 

Type IVb. Corresponds to the Th2-type immune response. Th2 T cells secrete the cytokines EL-4, EL-13, and EL-5, which promote B cell production of IgE and IgG4, macrophage deactivation as well as mast cell and eosinophil responses. The high production of EL-5 leads to an eosinophilic inflammation, which is the characteristic inflammatory cell type in many drug hypersensitivity reactions (Pichler 2003). In addition, there is a link to type I reactions because Th2 cells boost IgE production by EL-4/EL-13 secretion. Thus, type IVb reactions may actually be involved in the late phase allergic inflammation of the bronchi or nasal mucosa (asthma and rhinitis), which were initiated by IgE on mast cells or basophils. Another in vivo correlate might be infestations with nematodes, eosinophU-rich maculopapular exanthema, or other T cell-dependent diseases with hypereosinophilia. 

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