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Base pair duplex oligonucleotides, hydrogen

Recent reports indicate that divalent transition metal ions, such as Cu +, forming links between two artificial hydroxypyridone nucleobases can efficiently replace the hydrogen bonding between natural nucleobases, A-T and G-C, in oligonucleotides. Such artificial metal-mediated base pairs results in a moderate increase in the thermal stability of the duplex. They could lead to nucleic acid materials with novel chemical and physical properties. Such ohgonucleotide derivatives are of interest for the design of biosensors, nanomolecular wires, and switches. [Pg.3180]

Hydrogen-Bonding Patterns Observed inthe Base Pairs of Duplex Oligonucleotides... [Pg.77]


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Base pairing bases

Base pairs

Bases Base pair

DUPLEX

Duplexe

Duplexer

Hydrogen bases

Hydrogen pairing

Oligonucleotides base pairing

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