Barbiturates oxybate

BARBITURATES SODIUM OXYBATE Risk of CNS depression - coma, respiratory depression Additive depression of CNS Avoid co-administration. Caution even with relatively non-sedating antihistamines (cetrizine, desloratidine, fexofenadine, levocetirizine, loratidine, mizolastine) as they can impair performance of skilled tasks... 

Barbiturates. The UK manufacturer specifically contraindicates the use of sodium oxybate in patients taking barbiturates. ... 

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See also in sourсe #XX -- [ ]

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