Barbiturates bromine-containing

A more specific method of detecting barbituric acids is through the murexide reaction [86a, 173] and of thiobarbituric acids, through the iodine-azide reaction (Rgt. No. 142) [173]. Bromine-containing barbituric acids may be characterised by oxidation yielding bromine which then converts fluorescein into eosin (Rgt. No. 119). Larger amounts of barbituric acids and ureides, separated by TLC, can be removed from the layer by microsublimation and identified through their crystal form [8]. 

In this section, we consider the determinations based on the addition of bromine on double bonds. Most of the time, these addition reactions take place in nonaqueous media. We limit ourselves to recall the notions of iodine value and fat indices. Some drugs are determined by the addition of bromine on a double bond that their structures contain. We ll first consider cyclobarbital and hexobarbital, which are derived from barbituric acid ... 

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