Barbiturates aryl derivatives

In contrast, the 0-aryl derivative of Af-methyl-6-(hydroxyamino)-l,3-dimethylpyrimi-dine-2,4(1/7,3i7)-dione 44, prepared by reaction with 2,4-dinitrofluorobenzene (DNFB), yields the corresponding barbiturate 45 by a spontaneous [3,3]-sigmatropic rearrangement (equation 14). 

There is a very great demand for drugs for the relief of anxiety. This was formerly met by the use of alcohol, bromides or barbiturates, which carried the risk of abuse or dangerous toxicity. The first of the modern minor tranquilizers, introduced from 1946 onwards, were drugs described as skeletal muscle relaxants. These were mainly derivatives of polyhydric alcohols, but heterocyclic examples included metaxolone (161), which is related to the aryl ethers of glycerol, chlorzoxazone (162) and chlormezanone (163). Dantrolene sodium (164) is a muscle relaxant and CNS depressant. 

Aryl mercuric chloride was reacted with barbituric acid or thiobarbituric acid derivatives to... 

Organomercury compounds 538 have been synthesized by the reaction of barbituric acid or thiobarbituric acid derivatives 67 (X = O, R = H X = S, R = Ph) with aryl mercuric chloride under MWI using basic alumina as a solid support less time (1.5 2 min) and better yields (90 96%) (Scheme 106) were found as compared to the conventional method (99POL2641). 

The InCl3-catalyzed reaction of barbituric and thiobarbi-turic acid-derived enamines 107 with aryl aldehydes 106 and 3-(2-cyanoacetyl)indole 26 was described by Bhuyan and... 

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