Barbas, Carlos

Baba, Akio, 26 Banwell, Martin, 170 Barbas, Carlos F. Ill, 152 Baskaran, Sundarababu, 8 Basu, Amit, 40 Bavetsias, V., 100 Bergman, Robert, 122 Bernini, Roberta, 20 Blechert, Siegfried, 134 Bode, Jeffrey, 114 Bosch, Joan, 192 Braun, Manifred, 178 Breit, Bernhard, 148 Buchwald, Stephen L., 164... 

Enantioselective aldol reactions also can be used to create arrays of stereogenic centers. Two elegant ot-amino anion approaches have recently been published. Fujie Tanaka and Carlos F. Barbas III of the Scripps Institute, La Jolla, have shown (Org. Lett. 2004,6,3541) that L-proline catalyzes the addition of the aldehyde 6 to other aldehydes with high enantio- and diastereocontroJ. Keiji Maruoka of Kyoto University has developed (J. Am. Chem. Soc. 2004,126,9685) a chiral phase transfer catalyst that mediates the addition of the ester 9 to aldehydes, again with high enantio- and diastcrcocontrol. 

By CARLOS F. BARBAS III, CHRISTOPH RADER, DAVID J. SEGAL, BENJAMIN LIST, and JAMES M. TURNER... 

Amelie Karlstrom, Guofu Zhong, Christoph Rader, Nicholas A. Larsen, Andreas Heine, Robertsa Fuller, Benjamin List, Fujie Tanaka, Ian A. Wilson, Carlos F. Barbas, III and Richard A. Lemer, Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task. Proceedings of the National Academy of Sciences USA, 97 (2000), 3873-3883. 

OThis is the first example of an enantioselective, organocatalytic aldol addition, which went unnoticed for 30 years. Initiated, among others, by the work of Carlos Barbas III, David MacMillan and Benjamin List, only in recent years the thriving research area of organo-catalysls evolved from that original report. [65-67]... 

An impressive array of new catalysts for enantioselective homologation have been reported. Carlos F. Barbas 111 of Scripps/La Jolla has found (Angew. Chem. Int. Ed. 2007, 46, 5572) that the commercial amino acid 3 mediated the addition of dibydroxyacetone 2 to an aldehyde such as 1 to give the triol 4 with high enantio- and diastereocontrol. Takashi Ooi ofNagoya University has devised (J. Am. Chem. Soc. 2007,129, 12392) the catalyst 6 for the anti addition (Henry reaction) of nitro alkanes such as 5 to aldehydes. Takayoshi Arai of Chiba University has developed (Organic Lett. 2007, 9, 3595) a complementary catalyst (not shown) that mediated syn addition. Jonathan A. EUman of the University of California, Berkeley has uncovered (J. Am. Chem. Soc. 2007,129,15110) the catalyst 10 for the aza-Henry reaction. Yian Shi of Colorado State University has found (J. Am. Chem. Soc. 2007,129,11688) hgands for Pd that direct the absolute sense of the addition of 13 to dienes such as 12. 

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