BAR domain

Keywords cell signaling lipid rafts BAR domains membrane curvature membrane elasticity PIP2 diffusion mean-field model coarse-grained theory Poisson-Boltzmann theory Cahn-Hilliard equations... 

Ultimately, sequestering charged lipids could potentially lead to a new stable state, in which bilayer bending forces favor membranes with local nonzero curvature. Moreover, the mechanism for coupling local lipid composition with membrane curvature may be complemented by a "local spontaneous curvature" mechanism [88], whereby the asymmetry between the spontaneous shapes of two monolayers is achieved by insertion of amphipathic N-terminal helices of certain BAR domains into the lipid polar head-groups region on one side of the membrane [7,88-95]. According to this mechanism, the insertion of an amphipathic... 

Figure 3 Steady-state shapes upon binding of the Amphiphysin N-BAR domain dimer plots show upper leaflet contours of membranes with different bending rigidities and with N-helix insertions of various depths. The membrane patches have -0.4e/nm2 average surface charge densities (corresponding to 0.3 PS lipid fractions) on both layers. The orientation of the BAR domain used in these calculations is the same as in Figure 2. For all systems, a nonzero spontaneous curvature c0 domain was defined for a membrane patch inside the BAR projection area shown in panel L and extending 20 A away from the projected zone. The values for c0 in the range of 0-1/70 A 1 were used.

Ayton, G.S., Blood, P.D., Voth, G.A. Membrane remodeling from N-BAR domain interactions Insights from multi-scale simulation. Biophys. J. 2007, 92, 3595-602. 

Habermann, B. The BAR-domain family of proteins A case of bending and binding EMBO Rep. 

Dawson, J.C., Legg, J.A., Machesky, L.M. BAR domain proteins A role in tubulation, scission and actin assembly in dathrin-mediated endocytosis. Trends. Cell Biol. 2006,16, 493-8. 

Masuda, M., Takeda, S., Sone, M., Ohki, T., Mori, H., Kamioka, Y., Mochizuki, N. Endophilin BAR domain drives membrane curvature by two newly identified structure-based mechanisms. EMBO J. 2006, 25, 2889-97. 

Yin, Y., Arikhipov, A., Schulten, K. Simulations of membrane tabulation by lattices of amphi-physin N-BAR domains. Structure 2009,17, 882-92. 

Low C, Weininger U, Lee H, Schweimer K, Neundorf I, Beck-Sickinger AG, Pastor RW, Balbach J (2008) Structure and dynamics of helix-0 of the N-BAR domain in lipid micelles and bilayers. Biophys J 95 4315 323... 

Zimmerberg J, McLaughlin S (2004) Membrane curvature how BAR domains bend bilayers. Curr Biol 14 R250-R252... 

Arkhipov A, Yin Y, Schulten K (2008) Foin-scale description of membrane sculpting by bar domains. Biophys J 95(6) 2806-2821... 

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