Endocytosis dathrin-mediated

Ungewickell, E. J., and L. Hinrichsen. (2007). Endocytosis dathrin-mediated membrane budding. Curr Opin Cell Biol, Vol.l9, p>p.417-425. 

Dawson, J.C., Legg, J.A., Machesky, L.M. BAR domain proteins A role in tubulation, scission and actin assembly in dathrin-mediated endocytosis. Trends. Cell Biol. 2006,16, 493-8. 

Metzler M, Legendre-Guillemin V, Gan L, Chopra V, Kwok A, McPherson PS, et al. HIPl functions in clathrin-mediated endocytosis through binding to dathrin and adaptor protein 2. J Biol Chem 2001 276 39271-6. 

The main route of endocytosis is through the cla-thrin-mediated pathway. Specialized transient pits about 100 nm in diameter and coated by the structural protein dathrin can cover up to 2% of the cytosolic face of a plasma membrane. Roth and Porter first described these pits in 1964 as invaginations of the plasma membrane covered with bristle-like projections. The same bristles could be seen covering vesicles just inside the membrane deeper in the cell the vesicles had lost their bristles. They correcdy hypothesized that the bristle-coated pits invaginated to form coated vesicles, which then lost their coat and fused to form a storage granule. 

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