Bacteriochlorins, biological

These reactions allow access to chlorins, bacteriochlorins, and isobacteriochlo-rins having biological activity (Scheme 27).132 The key marine metabolite oroidin... 

The diimide-reduction approach was later employed by Bonnett et al. for preparing the /Mcso-tetra(m-hydroxyphe-nyl)-bacteriochlorin H2(m-THPBC). In vivo biological assays of mmor response showed that H2(m-THPBC) was a very active tumor photosensitizer. However, it was relatively unstable when compared with H2(m-THPC) in vitro. About 25 to 33% of the H2(m-THBPC) within the cells was oxidized to chlorin in 24 hours. ... 

Chlorin one of the basic ring structures of the porphyrins. Using the numbering system of the Commission of Nomendature of Biological Chemistry, 1960 (see Porphyrins), C. is 17,18-dihydroporphyrin. With the introduction of the term porphyrin, terms in the original Fischer nomenclature, such as C, por-phin, phorbin, bacteriochlorin, etc., are now superfluous. 

The most important chromophores in biological systems are chlorophylls and bacteriochlorophylls. They derive from chlorine and bacteriochlorine. Porphyrins derive from porphine (Figure 14.3). The two protons on the nitrogen... 

Adams, K.R., Berenbaum, M.C., Bonnett, R., Nizhnik, A.N., Salgado, A., and Valles, M.A., Second generation tumour photosensitizers the syntheses and biological activity of octaethyl chlorines and bacteriochlorins with graded amphiphilic character, /. Chem. Soc. Perkin Trans. 1, 1465,1992. 

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