Baclofen observational studies

Observational studies In a multicenter study of baclofen 60 mg/day for abstinence initiation in severe cocaine-dependent individuals, there was no effect on cocaine use after 8 weeks [37. ... 

A combination of enzymatic resolution and orthoester rearrangement has been used by Brenna in a short synthesis of (R)-(-)-baclofen 503 (Scheme 6.79) [123a]. R) or (S)-3-Methyl-2-phenylbutylamine 506 were recently obtained using the same strategy (Scheme 6.79) [123bj. A Claisen-Johnson rearrangement of a benzyl vinyl ether studied by Raucher provided substituted arenes 510. Better results were observed with electron donating substituted arenes. This reaction has been extended to indole derivatives 511 (Scheme 6.79) [124]. 

Nervous system A randomised, double-blind, crossover study of 12 healthy adults with risperidone demonstrated significant dose-dependent effects on balance control. This effect was observed at low doses with no clinically detectable extrapyramidal symptoms [249 -]. Pisa syndrome is a dystonia affecting cervical and lumbar musculature that has been reported with risperidone, paliperidone and chlorpromazine. A case is presented of a 31-year-old male with MS and FDD who developed Pisa syndrome after chronic risperidone treatment showed improvement with lurasidone, but recurrence with chlorpromazine [250 ]. Another case in a 23-year-old female with history of seizure due to periventricular focal nodular heterotopia occurring 12 months after risperidone treatment she was eventually managed on olanzapine and baclofen PSI ]. A case of persistent Parkinsonism in an 84-year-old male after 5 months of risperidone (2 mg per day) is reported [252 ]. Other dystonic phenomena reported with risperidone include dislocation of the temporomandibular joint [253 ]. 

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